ABSTRACT

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

chapter 2|158 pages

Process Optimization

chapter 3|104 pages

Hazardous Reactions

chapter 4|20 pages

Catalytic Reactions

chapter 5|22 pages

Grignard Reagent and Related Reactions

chapter 6|12 pages

Challenging Reaction Intermediates

chapter 7|22 pages

Protecting Groups

chapter 8|34 pages

Reaction Solvents

chapter 9|18 pages

Base Reagent Selection

chapter 10|14 pages

Reagents for Amide Formation

chapter 11|22 pages

Various Reagent Surrogates

chapter 12|46 pages

Telescope Approach

chapter 13|54 pages

Stereochemistry

chapter 14|46 pages

Design of New Synthetic Route

chapter 15|162 pages

Reaction Workup

chapter 16|18 pages

Pharmaceutical Salts

chapter 17|12 pages

Solid Form