ABSTRACT

A complex disease involves many etiological and risk factors operating at multiple levels-molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize trea

part |2 pages

Part I: Organismal Level: What Is Required

chapter 1|22 pages

Food Intake and Energy Metabolism

chapter 2|8 pages

Glucose Homeostasis

chapter 3|18 pages

Optimal Glucose Homeostasis

chapter 4|4 pages

Bistability as a Fundamental Phenomenon

part |2 pages

Part II: Molecular Level: What Can Be Provided?

chapter 5|16 pages

Molecular Biology

chapter 6|10 pages

Biomolecular Network

chapter 7|14 pages

PI3K-AKT-TOR Pathway

part |4 pages

Part III: Mathematical Analysis of Complex Diseases

chapter 8|12 pages

Diseases Related to Metabolism

chapter 10|10 pages

Fundamental Decomposition

chapter 11|10 pages

Normal Phenotype

chapter 12|12 pages

Disease Phenotypes

chapter 13|4 pages

Tao of Diseases

chapter |10 pages

A. Optimization of Insulin Action

chapter C|6 pages

Singularity Theory

chapter |8 pages

E. Analysis of the Master Equation