ABSTRACT

This work shows how the cellular Potts model can be used as a framework for model building and how extended models can achieve even better biological practicality, accuracy, and predictive power. It focuses on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description.

part 1|2 pages

Part 1: Basic Cellular Potts Model and Applications

chapter 1|14 pages

Basic CPM

chapter 2|16 pages

HGF-Induced Cell Scatter

chapter 3|14 pages

Mesothelial Invasion of Ovarian Cancer

part 2|2 pages

Part II: Extended Cellular Potts Model and Applications

chapter 4|18 pages

Extended Cellular Potts Model

chapter 5|14 pages

Wound Healing Assay

chapter 7|22 pages

Tumor-Derived Vasculogenesis

chapter 9|24 pages

Cell Migration in Extracellular Matrices

part 3|2 pages

Part III: Appendix

chapter |4 pages

A Computational Implementation

chapter |12 pages

B Glossary

chapter 100|10 pages

Appendix C: Parameter Values

chapter |10 pages

D Color Insert