ABSTRACT

Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of

chapter |6 pages

Introduction

chapter 1|48 pages

Regression Models and Their Analysis

chapter 2|44 pages

Convex Design Theory

chapter 3|18 pages

Algorithms and Numerical Techniques

chapter 4|16 pages

Optimal Design under Constraints

chapter 5|24 pages

Nonlinear Response Models

chapter 6|36 pages

Locally Optimal Designs in Dose Finding

chapter 7|64 pages

Locally Optimal Designs in PK/PD Studies

chapter 8|42 pages

Adaptive Model-Based Designs

chapter 9|38 pages

Other Applications of Optimal Designs

chapter 10|6 pages

Useful Matrix Formulae