ABSTRACT

Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty-such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that

chapter 1|16 pages

Introduction

chapter 2|50 pages

Linear systems

chapter 3|48 pages

Nonlinear systems

chapter 4|36 pages

Negative feedback systems

chapter 5|34 pages

Positive feedback systems

chapter 6|26 pages

Model validation using robustness analysis

chapter 7|44 pages

Reverse engineering biomolecular networks