ABSTRACT
From a geometric perspective, this book reviews and analyzes the structural principals of proteins with the goal of revealing the underlying regularities in their construction. It also reviews computer methods for structure analysis and the automatic comparison and classification of these structures with an analysis of the statistical significance of comparing different shapes. Following an analysis of the current state of the protein classification, the authors explore more abstract geometric and topological representations, including the occurrence of knotted topologies. The book concludes with a consideration of the origin of higher-level symmetries in protein structure.
TABLE OF CONTENTS
chapter Chapter 1|15 pages
Introduction
part 1|114 pages
Geometry
chapter Chapter 2|30 pages
Ellipsoids and embedding
chapter Chapter 3|44 pages
Sticks to strings
chapter Chapter 4|38 pages
Sheets and barrels
part 2|78 pages
Classification
chapter Chapter 5|26 pages
Networks and domains
chapter Chapter 6|21 pages
Protein structure comparison
chapter Chapter 7|29 pages
Classification and fold spaces
part 3|60 pages
Topology
chapter Chapter 8|38 pages
Folds, tangles and knots
chapter Chapter 9|20 pages
Structure prediction and modelling
part 4|39 pages
Symmetry