ABSTRACT

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials prov

chapter 1|14 pages

What Is a Randomized Controlled Trial?

chapter 2|10 pages

Bias

chapter 3|18 pages

How Many Patients Do I Need?

chapter 4|22 pages

Methods of Allocation

chapter 5|8 pages

Assessment, Blinding, and Placebos

chapter 6|22 pages

Analysis of Results

chapter 7|54 pages

Further Analysis: Binary and Survival Data

chapter 8|16 pages

Monitoring Accumulating Data

chapter 9|18 pages

Subgroups and Multiple Outcomes

chapter 10|10 pages

Protocols and Protocol Deviations

chapter 12|12 pages

Meta-Analyses of Clinical Trials