ABSTRACT

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

chapter 1|98 pages

Electrospray Ionization Mass Spectrometry

History, Theory, and Instrumentation

chapter 2|40 pages

Nanospray Electrospray Ionization Development

LC/MS, CE/MS Application

chapter 6|26 pages

Electrospray Ionization Mass Spectrometry of Peptides and Proteins

Methodologies and Applications