ABSTRACT

Focusing on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, noninferiority/supe

chapter 1|24 pages

Introduction

chapter 3|34 pages

Comparing Means

chapter 4|34 pages

Large Sample Tests for Proportions

chapter 5|28 pages

Exact Tests for Proportions

chapter 7|24 pages

Comparing Time-to-Event Data

chapter 8|28 pages

Group Sequential Methods

chapter 9|42 pages

Comparing Variabilities

chapter 10|22 pages

Bioequivalence Testing

chapter 11|24 pages

Dose Response Studies

chapter 12|24 pages

Microarray Studies

chapter 13|28 pages

Bayesian Sample Size Calculation

chapter 14|18 pages

Nonparametrics

chapter 15|44 pages

Sample Size Calculation in Other Areas