ABSTRACT

In an effort to go beyond immune-based therapies, researchers are now considering the implications of apoptosis dysregulation during HIV-induced immunodeficiency. This work provides the first comprehensive compendium of the progress made in understanding the process of cell death related to HIV and the potential breakthroughs in treatment that offer much promise. Combining the work of more than two-dozen top researchers, this seminal volume provides clinicians and researchers with an excellent reference, while also serving as an incubator to stimulate future research. It explains the fundamental biology involved with apoptosis, explains its clinical impact in HIV, and examines the newest therapeutic approaches.

chapter 1|18 pages

Lentiviral Biology and Cell Death

chapter 2|14 pages

Regulation of Apoptosis

chapter 3|20 pages

Approaches Used to Detect Apoptosis

chapter 6|14 pages

Cell Death in HIV Infection: gp120

chapter 7|18 pages

Vpr

chapter 9|12 pages

HIV-1 Tat and Apoptotic Death

chapter 10|14 pages

HIV Protease (PR) and Cell Death

chapter 11|14 pages

Immune Activation

chapter 15|18 pages

Autologous Cell-Mediated Killing

chapter 17|14 pages

Nonapoptotic HIV-Induced T Cell Death