ABSTRACT
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosph
TABLE OF CONTENTS
section |31 pages
Introduction
section Section A|1 pages
Specific Phosphodiesterase Families—Regulation, Molecular and Biochemical Characteristics
section Section B|46 pages
Nonmammalian Phosphodiesterases
section Section C|41 pages
Phosphodiesterases Functional Significance: Gene-Targeted Knockout Strategies
section Section D|52 pages
Compartmentation in Cyclic Nucleotide Signaling
section Section E|166 pages
Phosphodiesterases as Pharmacological Targets in Disease Processes
section Section F|119 pages
Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents
