ABSTRACT

Top Investigators Explore the Complexities of Angiogenesis Cancer Research

The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bev

part |2 pages

Part I Angiogenesis in Cancer

part |2 pages

Part II Targeting Angiogenesis for Cancer Therapy

chapter 14|36 pages

Vascular Disrupting Agents

part |2 pages

Part III Translating Angiogenesis Inhibitors to the Clinic

chapter 18|12 pages

Clinical Trial Design and Regulatory Issues

chapter 20|30 pages

Noninvasive Surrogates

chapter 21|20 pages

Pharmacodynamic Markers in Tissues

chapter 22|16 pages

Blood-Based Biomarkers for VEGF Inhibitors

part |2 pages

Part IV Treatment of Specific Cancers with Angiogenesis Inhibitors

chapter 23|14 pages

Antiangiogenic Therapy for Colorectal Cancer

chapter 24|10 pages

Combined Modality Therapy of Rectal Cancer

chapter 25|28 pages

Antiangiogenic Therapy for Breast Cancer

chapter 26|40 pages

Antiangiogenic Therapy for Lung Malignancies

chapter 27|28 pages

Antiangiogenic Therapy for Prostate Cancer

chapter 29|22 pages

Antiangiogenic Therapy for Gliomas

chapter 31|22 pages

Antiangiogenic Therapy for Melanoma

chapter 32|16 pages

Sunitinib and Renal Cell Carcinoma