ABSTRACT
This title presents a comprehensive overview of the principles, methods and fundamental theories used in the separation, quantification and analysis of individual compounds and substances. It identifies recent advances, mathematical relationships and useful design techniques for optimal system operation and control of chemical and chromatographic processes.
The mechanics of retention: introduction to chromatography theory; the control of chromatographic retention and selectivity (the Plate theory); the distribution coefficient and its control of solute retention; the theory of mixed phases in chromatography; programming techniques; extensions of the Plate theory. The mechanics of dispersion: the dynamics of peak dispersion; the rate theory equations; extra-column dispersion; exeprimental validation of the Van Deemter equation; the measurement of solute diffusivity and molecular weight; chromatography column design; chromatography column design - the design of open tubular columns for GC.
