ABSTRACT

Sample size calculation plays an important role in clinical research. It is not uncommon, however, to observe discrepancies among study objectives (or hypotheses), study design, statistical analysis (or test statistic), and sample size calculation. Focusing on sample size calculation for studies conducted during the various phases of clinical resea

chapter 1|20 pages

Introduction

chapter 3|33 pages

Comparing Means

chapter 4|32 pages

Large Sample Tests for Proportions

chapter 5|32 pages

Exact Tests for Proportions

chapter 7|23 pages

Comparing Time-to-Event Data

chapter 8|25 pages

Group Sequential Methods

chapter 9|42 pages

Comparing Variabilities

chapter 10|23 pages

Bioequivalence Testing

chapter 11|15 pages

Nonparametrics

chapter 12|34 pages

Sample Size Calculation in Other Areas